磷酸酶Wip1基因敲除表型及机制研究进展

doi:10.11843/j.issn.0366-6964.2017.12.002

Abstract

Abstract:

Wip1 (Wild-type p53-induced phosphatase1) is a member of PP2C (The type 2C family of protein phosphatases) family of phosphatases, which plays important roles in DNA damage repair and has attracted increasing attention as a oncogene. Wip1 knockout mice were viable, but exhibited reduced longevity, along with multiple-system abnormalities, including reproductive system, immune system, endocrine system and nervous system. The detailed phenotypes included male reproductive organ atrophy, male infertility, increased susceptibility to pathogens, diminished T-and B-cell function, insulin resistance, impaired body weight, declined fat mass,elevated anxiety-and depression-like behaviors and so on. The studies for the underlying molecular mechanisms further demonstrated that Wip1 played critical roles in a variety of physiological and pathological processes through dephosphorylating different substrate proteins. Therefore, in this review, we comprehensively discussed the phenotypes caused by Wip1 knockout in mouse as well as the possible underlying molecular mechanisms, which may provide information for further understanding the biological function of Wip1, and the possible mechanisms underlying the physiological and pathological processes in mammals.

CLC Number:

WANG Bing-yuan, LIU Zhi-guo, MU Yu-lian. Research Progress of Wip1 Phosphatase Knockout Phenotypes and Underlying Mechanisms[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2017, 48(12): 2232-2238.

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References

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Research Progress of Wip1 Phosphatase Knockout Phenotypes and Underlying Mechanisms

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